CLIA SS-B
Chemiluminescence kit for the detection of SS-B antibodies in human serum or plasma.
Available
Chemiluminescence kit for the detection of SS-B antibodies in human serum or plasma.
| Catalog Number: | CL-SSB050 |
|---|---|
| Size: | 50 tests |
| Regulatory status: | CE IVD |
| Clinical topic: | Immunology & Autoimmune Diseases |
| Diagnostic panel: | Rheumatic Diseases |
SS-B/La antigen is a phosphoprotein with molecular weight 48 kDa localized mostly in a complex with various RNA molecules in both the cell nucleus and the cytoplasm.
Autoantibodies against SS-B/La are found alone very rarely. They are more frequently associated with antibodies against SS-A/Ro antigen. Antibodies against SS-B/La are typical mainly for Sjögren’s syndrome (50-60%), particularly in extraglandular manifestations in lung, kidney, and liver. Anti-SS-B/La are positive in 15% of patients with systemic lupus erythematodes (SLE). The antibodies may be present few years before the disease starts. They are detected together with anti-SS-A/Ro antibodies in neonatal lupus.
Antibodies against SS-B/La as well as anti-Ro52 antibodies significantly increase a risk of congenital atrioventricular block (CAVB).
Antigen Used: Recombinant SS-B/La antigen.
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Measuring range | 0,5-320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | The kits are CE-IVD certified and intended for professional use. |