CLIA Sm
Chemiluminescence kit for the detection of Sm antibodies in human serum or plasma.
Available
Chemiluminescence kit for the detection of Sm antibodies in human serum or plasma.
| Catalog Number: | CL-Sm0050 |
|---|---|
| Size: | 50 tests |
| Regulatory status: | CE IVD |
| Clinical topic: | Immunology & Autoimmune Diseases |
| Diagnostic panel: | Rheumatic Diseases |
Sm is a small nuclear ribonucleoprotein composed of several protein autoantigens designated B, B1, D, E, F, and G, which range in size from 11 kD to 26 kD. Sm is a part of the U1-snRNP ribonucleoprotein complex, also known as Sm/RNP complex. Sm (Smith) antigen, the ribonucleoprotein nucleus is common to all snRNPs. Antibodies to Sm antigen and U1-snRNP specific proteins (RNP 68, RNP A, RNP C) are often found together.
Anti-Sm antibodies are highly specific for systemic lupus erythematosus (SLE). They are found in 20–30% of patients with SLE and represent an important tool in SLE serological diagnostics. Anti-Sm antibody levels remain relatively constant over time in patients with SLE and occur usually in patients who also have U1-snRNP antibodies.
Antigen Used: Native Sm antigen.
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Measuring range | 0,5-320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | The kits are CE-IVD certified and intended for professional use. |