CLIA Jo-1
Chemiluminescence kit for the detection of Jo-1 antibodies in human serum or plasma.
Available
Chemiluminescence kit for the detection of Jo-1 antibodies in human serum or plasma.
| Catalog Number: | CL-Jo1050 |
|---|---|
| Size: | 50 tests |
| Regulatory status: | CE IVD |
| Clinical topic: | Immunology & Autoimmune Diseases |
| Diagnostic panel: | Rheumatic Diseases |
Jo-1 antigen is a histidyl-tRNA synthetase enzyme localized mainly in the cytoplasm. It is a member of the amino acyl-tRNA synthetase family of enzymes found in all nucleated cells. Anti-Jo-1 antibodies are highly specific for myositis. They are associated with polymyositis (20-40%). Less frequently, these antibodies are also found in dermatomyositis and myositis related to other connective tissue systemic diseases.
Anti-Jo-1 antibodies occur in up to 50% of patients with interstitial pulmonary fibrosis and symmetrical polyarthritis. More than 70% of patients positive for Jo-1 antibodies have interstitial lung disease. The anti-Jo-1 antibodies level corresponds with the disease activity.
The antisynthetase syndrome comprises presence of anti-Jo-1 antibodies, myositis, interstitial lung disease, rheumatoid arthritis, or Raynaud's phenomenon. The disease manifestation differs depending on the type of anti-synthetase antibody (most often anti-Jo-1 antibody).
Antigen Used: Recombinant Jo-1 antigen.
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Measuring range | 0,5-320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | The kits are CE-IVD certified and intended for professional use. |