CLIA Scl-70
Chemiluminescence kit for the detection of Scl-70 antibodies in human serum or plasma.
Available
Chemiluminescence kit for the detection of Scl-70 antibodies in human serum or plasma.
| Catalog Number: | CL-Scl050 |
|---|---|
| Size: | 50 tests |
| Regulatory status: | CE IVD |
| Clinical topic: | Immunology & Autoimmune Diseases |
| Diagnostic panel: | Rheumatic Diseases |
The Scl-70 antigen is a type I DNA topoisomerase. It has a native molecular weight of 100 kDa. The enzyme is degraded to a protein of 70 kDa and less. Anti-Scl-70 antibodies bind to a native form of the antigen as well as to proteolysis products with lower molecular weights.
Presence of Anti-Scl-70 antibodies is highly specific serological marker for diffuse form of systemic scleroderma. They are present in 20-40% of individuals with systemic scleroderma. They indicate worse disease prognosis, and higher probability of musculoskeletal system and organ affections (lung fibrosis, proteinuria, heart damage). Anti-Scl-70 antibodies are rarely present in localized form of scleroderma. The antibody level corresponds with the disease activity.
Antigen Used: A mixture of native and recombinant Scl-70 antigens.
| Assay stability | 30 days on board stability / In use stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Measuring range | 3-320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |
| Complementary products | Wash buffer, Anchor® Tips, Stackable cuvettes, Trigger solutions |
| Note | The kits are CE-IVD certified and intended for professional use. |