CLIA Rubella IgM

• Detection of IgM antibodies to Rubella virus
• Detection of Rubella disease
• Intended for human serum and plasma
• Purified and inactivated antigen from HPV-77 strain with a high content of specific immunodominant epitopes used

Rubella is an exanthem viral disease of children and adolescents where it is a benign disease terminating without any lasting effects. The virus is transmitted by droplet infection or via the placenta.

Rubella can be a very serious maternal infection; the virus entering through the placenta often causes miscarriages or birth defects. The risk of embryo defects decreases with the length of pregnancy the highest risk is during the first trimester. Rubella is one of the infections of TORCH syndrome.

Reinfections occur more frequently in vaccinated individuals than in naturally immune ones. Most of these reinfections pass without any symptoms. Rubella reinfections in pregnancy seldomly lead to the infection of the fetus.

Both IgM and IgG antibodies are induced by acute infection. Class IgG antibodies remain for a long time, usually for the whole life. A significant increase of IgG antibody levels occurs also after vaccination even though the titers of these antibodies are generally lower than after undergoing natural infection.